Br J Cancer. 2006 Feb 21; [Epub ahead of print] Related Articles, Links
Mycosis fungoides: is it a Borrelia burgdorferi-associated disease?
Mycosis fungoides: is it a Borrelia burgdorferi-associated disease?
Tothova SM, Bonin S, Trevisan G, Stanta G.
1ICGEB - International Centre for Genetic Engineering and Biotechnology, 99 Padriciano, Trieste 34012, Italy.
Mycosis fungoides (MF) is the most frequently found cutaneous T-cell lymphoma with an unknown aetiology. Several aetiopathogenetic mechanisms have been postulated, including persistent viral or bacterial infections. We looked for evidence of Borrelia burgdorferi (Bb), the aetiologic agent of Lyme disease (LD), in a case study of MF patients from Northeastern Italy, an area with endemic LD. Polymerase chain reaction for the flagellin gene of Bb was used to study formalin-fixed paraffin-embedded lesional skin biopsies from 83 patients with MF and 83 sex- and age-matched healthy controls with homolocalised cutaneous nevi. Borrelia burgdorferi-specific sequence was detected in 15 out of 83 skin samples of patients with MF (18.1%), but in none out of 83 matched healthy controls (P<0.0001). The Bb positivity rates detected in this study support a possible role for Bb in the aetiopathogenesis of MF in a population endemic for LD.British Journal of Cancer advance online publication, 21 February 2006; doi:10.1038/sj.bjc.6602997 www.bjcancer.com.
PMID: 16495924 [PubMed - as supplied by publisher]
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