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#3794 De: "mvilaltabufi" <mvilaltabufi@...>
Fecha: Vie, 4 de Abr, 2008 6:18 pm
Asunto: RE: Antinuclear antibodies are not increased in the early phase of Borrelia infection. Re: [Lyme-E] Lyme y ANA Positivo 		mvilaltabufi
Sin conexión Sin conexión
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Gracias Miguel. En las referencias de este artículo hay otros
relacionando Lyme y ANA positivo.
Saludos a todos,
Montse

--- En lyme_y_otras_zoonosis_cronicas_espanol@yahoogroups.com,
Miguel Ramírez Ortega <ramirezortega@...> escribió:
>
> http://www.ncbi.nlm.nih.gov/pubmed/15236512?
ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.P
ubmed_RVDocSum
>
>
> Ann Agric Environ Med. 2004;11(1):145-8. Links
> Antinuclear antibodies are not increased in the early phase of
Borrelia infection.
> Spiewak R, Stojek NM, Chmielewska-Badora J.
> Instytut Medycyny Wsi, ul. Jaczewskiego 2, 20-090 Lublin, Poland.
spiewak@...
>
> In the literature, there are case reports suggesting that Borrelia
burgdorferi infection may induce autoimmune diseases dependent on
antinuclear antibodies (ANA). The present study was undertaken in
order to verify this possibility in a prospective manner. The study
group comprised 78 consecutive patients (51 women and 27 men, median
age 41.5 years) referred to our Department for the serologic
diagnosis of Borrelia infection. The patients' sera were tested for
Borrelia-specific IgM and IgG (Recombinant Antigen Enzyme
Immunoassays, Biomedica). Antibodies against Borrelia were detected
in 31 (39.7 %) persons. 15 persons (19.2 %) had positive IgM,
another 15 (19.2 %)--positive IgG, and 1 person (3.2 %)--both IgM
and IgG. Frequent positivity of IgM antibodies suggests that persons
in the early phase of infection prevailed in the group. Tests for
anti-dsDNA, anti-RNP, anti-Sm antibodies, and a screening test for
systemic rheumatic diseases (ANA Rheuma Screen) were carried out
using Varelisa Enzyme Immunoassays (Pharmacia and Upjohn). The
spectrum of autoimmune diseases covered by these tests included SLE,
MCTD, Sjogren's syndrome, scleroderma, polymyositis, and
dermatomyositis. ANA were detected in 15 persons (19.2 %): anti-
dsDNA in 7 (9.0 %), anti-RNP in 1 (1.3 %), anti-Sm in 2 (2.6 %), and
ANA Rheuma Screen was positive in 6 persons (7.7 %). Statistical
analysis of differences in the ANA frequency between Borrelia-
positive and -negative groups was carried out using Fisher's exact
chi-square test (both without and with gender and age matching). No
significant differences were found between the groups. Based on the
above results, we conclude that there is no increase in the
frequency of antinuclear antibodies in the early phase of Borrelia
infection.
>
> PMID: 15236512 [PubMed - indexed for MEDLINE]
>

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#3793 De: "juancaqd" <juancaqd@...>
Fecha: Vie, 4 de Abr, 2008 6:07 pm
Asunto: Combination of Bacteriostatic and Bactericidal Drugs: Lack of Significant In Vitro Antagonism Between Penicillin, Cephalothin, and Rolitetracycline 		juancaqd
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Old principles die hard - check out this article from 1976.  Betty
 
 
Combination of Bacteriostatic and Bactericidal Drugs: Lack of Significant In Vitro Antagonism Between Penicillin, Cephalothin, and Rolitetracycline
FRANZ D. DASCHNERI
Combined action of subinhibitory
penicillin and rolitetracycline concentrations resulted in more pronounced inhibition
of growth than either drug alone. The higher activity of penicillin/
cephalothin in combination with rolitetracycline on some E. coli and S. aureus
strains might be due to a better access of rolitetracycline into bacterial cells
whose cell walls have been weakened by cell wall-active, bactericidal drugs.
Thus, growth ofpenicillin-induced spheroplasts ofE. coli and stable staphylococcal
L-forms was inhibited by much lower concentrations of rolitetracycline than
were the corresponding parent cells with intact cell walls

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#3792 De: Miguel Ramírez Ortega <ramirezortega@...>
Fecha: Mié, 2 de Abr, 2008 4:38 pm
Asunto: Antinuclear antibodies are not increased in the early phase of Borrelia infection. Re: [Lyme-E] Lyme y ANA Positivo 		miguelramire...
Sin conexión Sin conexión
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Ann Agric Environ Med. 2004;11(1):145-8.Click here to read Links

Antinuclear antibodies are not increased in the early phase of Borrelia infection.

Spiewak R, Stojek NM, Chmielewska-Badora J.

Instytut Medycyny Wsi, ul. Jaczewskiego 2, 20-090 Lublin, Poland. spiewak@...

In the literature, there are case reports suggesting that Borrelia burgdorferi infection may induce autoimmune diseases dependent on antinuclear antibodies (ANA). The present study was undertaken in order to verify this possibility in a prospective manner. The study group comprised 78 consecutive patients (51 women and 27 men, median age 41.5 years) referred to our Department for the serologic diagnosis of Borrelia infection. The patients' sera were tested for Borrelia-specific IgM and IgG (Recombinant Antigen Enzyme Immunoassays, Biomedica). Antibodies against Borrelia were detected in 31 (39.7 %) persons. 15 persons (19.2 %) had positive IgM, another 15 (19.2 %)--positive IgG, and 1 person (3.2 %)--both IgM and IgG. Frequent positivity of IgM antibodies suggests that persons in the early phase of infection prevailed in the group. Tests for anti-dsDNA, anti-RNP, anti-Sm antibodies, and a screening test for systemic rheumatic diseases (ANA Rheuma Screen) were carried out using Varelisa Enzyme Immunoassays (Pharmacia and Upjohn). The spectrum of autoimmune diseases covered by these tests included SLE, MCTD, Sjogren's syndrome, scleroderma, polymyositis, and dermatomyositis. ANA were detected in 15 persons (19.2 %): anti-dsDNA in 7 (9.0 %), anti-RNP in 1 (1.3 %), anti-Sm in 2 (2.6 %), and ANA Rheuma Screen was positive in 6 persons (7.7 %). Statistical analysis of differences in the ANA frequency between Borrelia-positive and -negative groups was carried out using Fisher's exact chi-square test (both without and with gender and age matching). No significant differences were found between the groups. Based on the above results, we conclude that there is no increase in the frequency of antinuclear antibodies in the early phase of Borrelia infection.

PMID: 15236512 [PubMed - indexed for MEDLINE]


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#3791 De: Miguel Ramírez Ortega <ramirezortega@...>
Fecha: Mié, 2 de Abr, 2008 4:17 pm
Asunto: Acquired transient autoimmune reactions in Lyme. Re: [Lyme-E] Lyme y ANA Positivo 		miguelramire...
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Scand J Rheumatol Suppl. 1988;75:314-7. Links

Acquired transient autoimmune reactions in Lyme arthritis: correlation between rheumatoid factor and disease activity.

Goebel KM, Krause A, Neurath F.

Department of Medicine, University Hospital, Marburg, West Germany.

Lyme spirochaetal disease (LSD) is a complex multisystem disorder which has been recognized as a separate entity due to its close geographic clustering of affected patients. The study aimed at evaluating the clinical and immunological features of LSD with chronic symptoms of meningoradiculitis, carditis and pauciarticular arthritis. Six patients with LSD and erosive arthritis who developed an increase of serum IgM rheumatoid factor (RF) which correlated with the inflammatory activity of the disease are described in detail. Besides raised IgG antibody titers to Borrelia burgdorferi (B. burgd.) antigen measured by ELISA technique, circulating immune complexes, antinuclear antibodies (ANA) and RF measured by laser nephelometric immunoassay were detected. Increased ANA and RF antibody rates suggest that LSD may closely be linked with transient autoimmune phenomena. Thus, in some cases, B. burgd. antigens might be able to produce a strong polyclonal B-cell stimulation, hence leading to an unspecific autoimmune reaction. But the question remains if transient unspecific autoimmune reactions actually take part in the pathogenesis of LSD.


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#3790 De: "mvilaltabufi" <mvilaltabufi@...>
Fecha: Mié, 2 de Abr, 2008 10:24 am
Asunto: Lyme y ANA Positivo 		mvilaltabufi
Sin conexión Sin conexión
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Hola a todos,
espero que estéis bien.
Yo fui ayer al especialista que me trata y resulta que tengo los
anticuerpos antinucleares más altos de lo normal (1:80), lo que según
parece indica riesgo de sufrir una enfermedad autoimmune.
Sabéis si esto podria estar relacionado con Lyme? Conocéis algún
artículo/estudio que relacione ANA positivo con Lyme?
Por lo general estamos mejor, pero los símptomas no desaparecen del
todo. Para la próxima visita voy a pedir un análisis de los CD-57. No
sé lo que es pero Burrascano dice que puede ayudar a ver si la
infección sigue activa y cuando acabar el tratamiento. ¿Algún
comentario al respeto? La cuestión es que el doctor quiere terminar el
tratamiento pronto y yo quisiera esperar a que desaparezcan los
símptomas.
Bueno, como siempre, os agradezco mucho vuestra ayuda.
Un abrazo!
Montse

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#3789 De: "antsettler" <sacorroto@...>
Fecha: Jue, 27 de Mar, 2008 3:56 pm
Asunto: quelantes e infecciones resistentes 		antsettler
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sorprendente

Titre du document / Document title
Chelator-induced dispersal and killing of Pseudomonas aeruginosa
cells in a biofilm
Auteur(s) / Author(s)
BANIN Ehud (1) ; BRADY Keith M. (2) ; PETER GREENBERG E. (1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Department of Microbiology, School of Medicine, University of
Washington, Seattle, Washington 98195-7242, ETATS-UNIS
(2) Department of Microbiology, Roy and Lucille Carver College of
Medicine, University of Iowa, Iowa City, Iowa 52242, ETATS-UNIS

Résumé / Abstract
Biofilms consist of groups of bacteria attached to surfaces and
encased in a hydrated polymeric matrix. Bacteria in biofllms are
more resistant to the immune system and to antibiotics than their
free-living planktonic counterparts. Thus, biofilm-related
infections are persistent and often show recurrent symptoms. The
metal chelator EDTA is known to have activity against biofilms of
gram-positive bacteria such as Staphylococcus aureus. EDTA can also
kill planktonic cells of Proteobacteria like Pseudomonas aeruginosa.
In this study we demonstrate that EDTA is a potent P. aeruginosa
biofilm disrupter. In Tris buffer, EDTA treatment of P. aeruginosa
biofilms results in 1,000-fold greater killing than treatment with
the P. aeruginosa antibiotic gentamicin. Furthermore, a combination
of EDTA and gentamicin results in complete killing of biofilm cells.
P. aeruginosa biofilms can form structured mushroom-like entities
when grown under flow on a glass surface. Time lapse confocal
scanning laser microscopy shows that EDTA causes a dispersal of P.
aeruginosa cells from biofilms and killing of biofilm cells within
the mushroom-like structures. An examination of the influence of
several divalent cations on the antibiofilm activity of EDTA
indicates that magnesium, calcium, and iron protect P. aeruginosa
biofilms against EDTA treatment. Our results are consistent with a
mechanism whereby EDTA causes detachment and killing of biofilm
cells.
Revue / Journal Title
Applied and environmental microbiology  (Appl. environ. microbiol.)
ISSN 0099-2240   CODEN AEMIDF
Source / Source
2006, vol. 72, no3, pp. 2064-2069 [6 page(s) (article)] (42 ref.)
Langue / Language
Anglais

Editeur / Publisher
American Society for Microbiology, Washington, DC, ETATS-UNIS (1976)
(Revue)

Mots-clés anglais / English Keywords
Bacteria ; Pseudomonadales ; Pseudomonadaceae ; EDTA ; Biofilm ;
Pseudomonas aeruginosa ; Chelating agent ;
Mots-clés français / French Keywords
Bactérie ; Pseudomonadales ; Pseudomonadaceae ; EDTA ; Biofilm ;
Pseudomonas aeruginosa ; Chélateur ;
Mots-clés espagnols / Spanish Keywords
Bacteria ; Pseudomonadales ; Pseudomonadaceae ; EDTA ; Biofilm ;
Pseudomonas aeruginosa ; Quelante ;
Localisation / Location
INIST-CNRS, Cote INIST : 7195, 35400015344857.0410

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#3788 De: "antsettler" <sacorroto@...>
Fecha: Do, 23 de Mar, 2008 9:51 am
Asunto: ifn 		antsettler
Sin conexión Sin conexión
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hola, si los lyme que se resuelven tienen mas alto el ifn, y si la
borrelia sube los niveles de il-10 de forma cronica y crea tolerancia
a su presencia, quizas haya algun tratamiento con interferon, estilo
hepatitis, conoceis alguno?
saludos despues de tanto tiempo,
pablo

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#3787 De: "Miguel" <mikijean@...>
Fecha: Lun, 17 de Mar, 2008 4:05 am
Asunto: Treat Lyme Disease with Over-The-Counter Chinese Herbal Medicines 		mikijean@...
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Treat Lyme Disease with Over-The-Counter Chinese Herbal Medicines

Wednesday, March 12, 2008 by: Luke J. Terry
 
(NaturalNews) A silent epidemic is ravaging our people, inflicting a large and harrowingly complex group of symptoms including arthritic conditions, autoimmune conditions, cognitive problems, and many more. This quiet, nearly undetectable bacterial pathogen has infected millions, and most of them don't even know it. This disease has been identified as the fastest-growing infectious disease in the US, as well as the number-one insect-borne pathogen in the US. Yet this only represents the known cases of a disease that is known to be dramatically under-reported, under-diagnosed, and very difficult to both detect and treat. Up to one-half the population may have been exposed to this disease, according to Lyme disease expert Dietrich Klinghardt, MD, of Seattle, WA.

Lyme disease is a clinical diagnosed constellation of symptoms caused by a related group of pathogens, chief among them borrelia bergdorferi. Lyme Disease (LD) became widely known in 1975 after a large number of children and adults near Lyme, Connecticut, began to show symptoms of rheumatoid arthritis. Juvenile rheumatoid arthritis is rare, and a team of researchers began to study the outbreak. It was discovered that all the children involved spent a great deal of time outdoors, and a high incidence of tick exposure was found. The pathogenic agent, a spirochetal bacterium, responsible for the disease, was discovered by a PhD biologist named Willy Bergdorfer. Thus this new pathogen was named for Dr. Bergdorfer: Borrelia Bergorferi. The group of researchers led by Dr. Bergdorfer found that LD is transmitted by a tick-borne vector to and from rodents and small mammals, deer, pets, and humans.

Lyme disease was first reported in California in 1978, and is now the most common tick-borne illness in California and the United States. Since Bergdorfer's work, other experts have discovered credible evidence of Lyme disease being transmitted via many more vectors, including mosquitoes, fleas, and even sexual contact, according to James Bowen, MD, of Portland, OR.

The complete clinical presentation of a patient with Lyme disease can present symptoms like many other diseases, including Multiple Sclerosis, Rheumatoid Arthritis, and many others. Because of this shape-shifting tendency, Lyme disease has been dubbed "the great imitator." However classical early-onset symptoms in humans may include pain, swelling in the joints, fever, headache, and fatigue -- fitting a pattern that is described in the classical Shang Han Lun (Theory of Cold-Induced Damage), an ancient text in oriental medicine that has been used to successfully differentiate and treat illnesses for more than 1500 years.

The symptoms of Lyme disease usually show up days or weeks after a tick bite, though 50% of all LD patients cannot recall a tick bite, and it has been estimated that only 1-3% of all tick bites lead to LD. Several co-infections are commonly found along with LD, including erhlichosis, babiosis, and other forms of bacterium that are transmitted via tick or other insect bites.

Diagnosis in western medicine is made through identification of clinical signs and symptoms. No CDC-approved screening tests are accurate enough to be called definitive. Western diagnostic testing includes blood tests for IgG and IgM antibodies, such as ELISA and Western Blot, both showing poor sensitivity and specificity. Many experts in the field now believe that the borrelia pathogen assaults the B-lymphocytes, which are the components of the immune system responsible for making antibodies. When the antibody-producing cells are impaired, the immune system is blinded to the pathogens -- and so are any diagnostic tests looking for antibodies. This mechanism may explain why many patients, both known Lyme carriers and those whose Lyme status is unknown, suffer from arthritic symptoms closely resembling those of Rheumatoid Arthritis or Lupus, yet not antibodies for Lupus or RA are found.

Thus the diagnosis must be made from looking at history, taking symptoms and general patterns into account. Diagnosis is additionally hampered by the co-infection factor, which may create a host of other sometimes strange symptoms.

The LD pathogen slowly makes its way through the body, the longer it remains in the body, the more severe the infection. The severity of the infection is categorized by western practitioners in one of three categories related to its progression in the body -- early disseminated, late disseminated, and chronic. The disease is most treatable early in the progression. Standard western care includes immediate treatment with quinolone or cephalosporin antibiotics for a minimum of 6 weeks.

Mainstream western medicine treatment, limited to antibiotic treatment, commonly fails to provide relief or cure, and often results in worsening of the infection due to the side effects of the antibiotic therapy. Chronic LD has proven to be a very difficult infection to cure. End-stage patients can be severely neurologically compromised, and may resemble neurosyphilis in its clinical presentation: dementia, confusion, memory loss, delusions, and, eventually, complete neurological breakdown. This makes sense, because Borrelia Bergdorferi is in the same order as syphilis, the spirochaetalis order. Spirochetes are characterized by a flexible, spiral shape, not unlike a drill bit.

With so many factors involved, LD is an incredibly complex infection to describe, let alone to treat, and it is beyond the scope of this paper to describe in detail the unusual life cycle and characteristics of the organism that make it so difficult to treat with western medicine. The prognosis according to Traditional Oriental Medicine, or TOM, is much rosier, and demonstrates the power and optimism of this 5000-year old system of medicine. TOM has had much success treating both syphilis and leptospirosis, two cousins of Lyme disease. All three bacterium belong to the spirochete family. There is a large body of evidence demonstrating effective TOM herbal approaches to treating treponema palladium, and leptospira interogans, responsible for syphilis and leptospirosis, respectively.

Syphilis kills many thousands of people each year, though treatment with both western and oriental medicine effects a cure. Leptospirosis, from the Leptospira, is spirochetal infection transmitted to humans via flies, mosquitos and other insects, from pigs and other livestock. The symptoms of leptospirosis approximate those of Lyme disease, presenting with headache, severe muscle aches, chills, fever, and conjunctivitis, with the severe form known as Weil's disease causing hemorrhages, jaundice, and kidney and liver dysfunction.

Though there is little direct evidence of TOM success treating LD, clinical experience and success in treating other spirochetes demonstrates the strong potential of Oriental Medicine for effecting a cure for Lyme disease patients. Subhuti Dharmananda, PhD describes how early-stage disseminated LD follows a classic Shang Han Lun pattern. He also portrays the Lyme disease progression as one that fits the stages documented in the Shang Han Lun, with jaundice and meningitis both demonstrating severe and deeply penetrated pathogenic influence.

Bob Flaws, Dipl.OM, describes a progression in three stages; in the initial stage, LD is categorized as huo dan, or Fire Toxin, with Gan Mao, or contraction-encroachment, which are the flu-like initial symptoms. The initial pattern, then is one of damp heat & evil toxin entering the body. At this stage the immune system, called "the righteous qi" in traditional oriental medicine, still mounts a strong response. Traditional doctors would expect to see a red tongue with a slimy or greasy yellow tongue coating, and a floating, rapid pulse, along with the previously mentioned musculoskeletal symptoms.

The second stage, according to Flaws, is one of heat toxins with righteous qi vacuity. Thus the pathogen is stronger than in the first pattern, and the body somewhat weaker. The tongue in this stage would be less red, and more swollen, signifying more spleen xu. The pulse may be surging, indicative of more floating, unsupported yang energy as the yin is slowly consumed in the process of fighting the pathogen. Reiterating earlier, it is important to catch this disease as early as possible, as the longer it remains unchecked in the body, the more it damages the body's resources.

This is evident in Flaw's description of the deepest stage, one of profound qi, blood, and yin deficiency. Signs and symptoms would include extreme fatigue and loss of strength, tinnitus, low back pain, knee pain and swelling, dry mouth and throat, five-centers heat, malar flushing, hair loss, memory loss, confusion, and torpor.

This complicated clinical picture requires the deft use of herbs. The patient experiences both strong excesses (the pathogen), and potentially deep immune system deficiencies. Thus the treatment may be best approached with custom-blended medicinals. However, due to reasons of cost and convenience, commercially available, pre-prepared herbal supplements, or "patent" preparations may supplement or substitute for custom-blended powdered or raw herb formulas.

To begin with, a list of herbs that have been found to be medically effective against various spirochetes including borrelia bergdorferi is as follows: Coptis (huang lian), Scute (huang qin), Phellodendron (huang bai), Forsythia (lian qiao), Isatis root (ban lan gen), Isatis leaf (da qing ye), Andrographis (chuan xin lian), Smilax Glabra(tu fu ling), Asploidis (zhi zi), and Artemesia Annua (qing hao). Of these herbals, all are strong heat-clearing herbs with well-demonstrated antibacterial qualities. Chief among this group is artemesia annua (qing hao), showing an incredible effectiveness against malaria, another insect-born, though very different pathogen. In particular, an active ingredient called arteanuin is used alone as a western treatment for malaria. Many malaria experts believe this "drug" combats malaria more effectively than any man-made drug currently available.

This herb is readily available as a concentrated patent formula (Health Concerns, Artestatin). Others such as Forsythia (lian qiao), Isatis roots & leaves (ban lan gen & da qing ye), and Andrographis (chuan xin lian), are well-demonstrated against leptospirosis, and are readily available in balanced patent formulas. Of all of the above listed herbs, the best single herb is probably tu fu ling. This herb, Smilax Glabra, is perhaps the most gentle, most neutral and least damaging to the body. The "atmospheric qualities" of Smilax Glabra, or the way that the herb affects the body's condition globally, are categorized as sweet and neutral, meaning it is both gentle and nourishing. Smilax has shown to be profoundly effective against both leptospirosis (in large clinical trials) and against LD (by clinical experience). Unfortunately, there are few if any commercial preparations of Smilax Glabra, despite its profound effectiveness and mild nature. It appears that Smilax Glabra is underappreciated as a medicinal agent.

In the realm of patents, for acute phase, massive doses of Yin Qiao San are appropriate, as it contains Forsythia (lian qiao), and its usage fits the initial pattern of disease. Far East Summit's alcohol preparation would be an excellent choice, as the alcohol would drive the medicine into the channels and tissues. In addition, Artestatin from Health Concerns presents itself as a very effective medicinal agent, as its concentration and aromatic preservation are excellent. It also contains Coptis (huang lian,) and a number of balancing herbs, too long to be listed here, to balance the cold, draining qualities of Artemeseia (qing hao) and Coptis (huang lian).

In the early stage, this may be enough to arrest the development of the LD pathogen and cure the disease. If symptoms are still developing, another more tonifying formula, one which still contains a strong complement of the heat-clearing antispirochetal herbs, would likely result in much better clinical outcomes. Specifically, Astra Isatis from Health Concerns contains plenty of tonics for qi, blood, yin, and yang, in addition to its chief herbs, Isatis (ban lan gen and da qing ye). This formulation derives its punch from using the roots and leaves of the Isatis plant.

A compelling body of evidence exists demonstrating the significant potential of tu fu ling, or smilax glabra, also known as sarsparilla, in treating spirochetal diseases. It is the author's hope that manufacturers of quality Oriental herbal products will notice this market opportunity, and create a product to serve the many patients suffering from Lyme disease and its coinfections.

References:

National Institutes of Health, 2003. Lyme Disease: The Facts, The Challenge, NIH Publication # 03-7045, p. 3

Sutter-Yuba Mosquito and Vector Control District, Lyme Disease, online at: (http://sutter-yubamvcd.org/Lyme%20Disease.asp)

(www.samento.com.ec/sciencelib/medmain.html)

Dharmananda, Subhuti, PhD, Lyme Disease: Treatment with Chinese Herbs, Institute of Traditional Medicine, online at: (http://www.itmonline.org/arts/lyme.htm)

(www.neuraltherapy.com/LymeALookBeyond6.pdf)

Burrascano Jr., Joseph J. MD, September 2005. Advanced Topics in Lyme Disease, p. 4-5.

Flaws, Bob, and Sionneau, Phillipe, 2005. Treatmentof Modern Western Medical Diseases with Chinese Medicine, Blue Poppy Press. P. 329-332.

William Morris, OMD. Personal correspondence, and personal experience.

Gaeddert, Andrew, 2006. Health Concerns Clinical Handbook, 4th Edition, p. 45-46.

(http://www.rain-tree.com/sarsaparilla.htm)

About the author

Luke completed a Master's Degree in Traditional Oriental Medicine in 2007 at Emperor's College of Traditional Oriental Medicine. He maintains a private practice in nutrition and herbology in Pacific Palisades, California.
He enjoys qigong, yoga, cycling, meditation, raw food nutrition, lucid dreaming, and hiking.
He is currently preparing for the National and State board examinations for licensure in acupuncture, while building a nutrition & wellness business with an area physician.
He lives with his sweetheart Sara, and their wild raw food cat, Mushroom.

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#3786 De: "Miguel" <mikijean@...>
Fecha: Sáb, 15 de Mar, 2008 5:41 pm
Asunto: Generics: Just as good? (LA Times - very long article) 		mikijean@...
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Generics: Just as good?

template_bas
template_bas
As generic drugs become more widely used, some doctors and patients question whether they are as effective as brand names.
By Melissa Healy, Los Angeles Times Staff Writer
March 17, 2008
IN the contentious debate over insuring Americans' health, the value of generic prescription drugs is a rare point of consensus. Patients, physicians, employers, politicians -- all hail generics as powerful treatment for a swelling healthcare tab. On average, these copycat medicines cost less than a third of the brand-name drugs they mimic. In turn, the competition they provide drives down the cost of those first-to-market drugs.

Officials of the Food and Drug Administration insist this feat of economics comes without any compromise to a medicine's effectiveness. To be marketed in the United States, these low-cost medicines must be approved by the FDA, which ensures they are "bioequivalent" to their brand-name counterparts -- the same dose of the same active ingredient, delivered in the same way, and manufactured according to the same standards of quality.

The Generic Pharmaceutical Assn. touts them with a slightly catchier slogan: "Same Medicine. Same Results." But sometimes, patients and their doctors beg to differ.

A switch from a long-used brand-name drug to its generic equivalent can, on occasion, bring a shifting profile of side effects. In a number of cases documented in medical journals and recounted in interviews with physicians, a generic version of what is often called a "pioneer" drug simply doesn't appear to work as well for many patients.
Use link to continue...

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#3785 De: "juancaqd" <juancaqd@...>
Fecha: Sáb, 15 de Mar, 2008 9:15 am
Asunto: Antibiotics 'block nerve damage' 		juancaqd
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http://news.bbc.co.uk/1/hi/health/4147043.stm
Antibiotics 'block nerve damage'
 
Antibiotics may protect against Alzheimer's disease
 
A family of antibiotics including penicillin may help prevent nerve damage in a variety of neurological diseases, research has found.
 
In lab tests on mice a team from Johns Hopkins University in Baltimore found the drugs turn on protective genes
 
This may have a beneficial effect on conditions such as dementia, stroke and epilepsy and Lou Gehrig's disease.
 
However, the Nature study stresses it is too soon to recommend the use of antibiotics for this purpose.
  This approach has potential applications in numerous neurologic and psychiatric conditions.
Professor Jeffrey Rothstein
 
There is concern that the widespread over-use of antibiotics is leading to increased levels of resistance, rendering the drugs of less and less use.
 
In the brain, a chemical called glutamate normally excites nerves so that electrical signals can travel from one to the next.
 
But too much of the chemical can over stimulate and kill nerves, leading to disease.
 
Antibiotics appear to tackle the problem by triggering genes which control production of a protein called GLT1, which can transport excess glutamate away from nerve endings.
 
Warning
 
Researcher Professor Jeffrey Rothstein said: "It would be extremely premature for patients to ask for or take antibiotics on their own.
 
"Only a clinical trial can prove whether one of these antibiotics can help and is safe if taken for a long time."
 
The researchers engineered mice to develop the equivalent of Lou Gehrig's disease, which in people causes progressive weakness and paralysis and ends in death, usually within three to five years of diagnosis.
 
The animals were given daily injections of an antibiotic called ceftriaxone just as symptoms began to develop.
 
The drug appeared to delay both nerve damage, and symptoms, and extended survival by 10 days compared to untreated animals.
 
Professor Rothstein said: "We're very excited by these drugs' abilities.
 
"They show for the first time that drugs, not just genetic engineering, can increase numbers of specific transporters in brain cells."
 
"This approach has potential applications in numerous neurologic and psychiatric conditions that arise from abnormal control of glutamate."
 
Further research
 
The researchers plan a major clinical trial in the spring to investigate further the potential of the drug in treating Lou Gehrig's disease.
  It is far too early to consider prescribing antibiotics for these human conditions.
Rebecca Wood
 
Ceftriaxone is currently used to treat bacterial infections in the brain.
 
In tests penicillin, which comes from the same family, protected nerve cells best in lab dishes, but ceftriaxone produced the best results in mice - possibly because it more easily crosses from the blood to the brain.
 
However, glutamate damage is only aspect of Lou Gehrig's disease, so the drug treatment could not prevent the animals from eventually dying.
 
Professor Rothstein said the challenge would be to find drugs that protect against the other causes of cell death.
 
"The combination might offer a real therapy, much like using drug combinations to treat cancer."
 
Rebecca Wood, of the Alzheimer's Research Trust, described the study as "potentially exciting".
 
"This is an original and logical approach. However, as the authors have stated, it is far too early to consider prescribing antibiotics for these human conditions.
 
"We don't yet know whether they will work in people, and since GLT1 loss is only part of the problem in these human diseases, a combination of various therapies will probably be needed.
 
"While antibiotics have been used against bacterial infections for 50 years, more research will be needed into the effects of long-term antibiotic use."

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#3784 De: "juancaqd" <juancaqd@...>
Fecha: Vie, 14 de Mar, 2008 10:27 pm
Asunto: Postmortem confirmation of Lyme carditis with polymerase chain reaction. 		juancaqd
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1: Cardiovasc Pathol. 2008 Mar-Apr;17(2):103-7. Epub 2007 May 11.
 Links
Postmortem confirmation of Lyme carditis with polymerase chain reaction.
Tavora F, Burke A, Li L, Franks TJ, Virmani R.
 
Department of Pulmonary and Mediastinal Pathology, Armed Forces Institute of Pathology, Washington, DC, USA.
 
BACKGROUND: Cardiac involvement in Lyme disease is uncommon and typically manifests clinically by conduction disturbances. Postmortem identification of Borrelia burgdorferi has never been reported in a case of Lyme carditis. METHODS AND RESULTS: We describe the case of a 37-year-old Caucasian man with a 1-month history of fevers, rash, and malaise who died unexpectedly on the day after he underwent medical evaluation. The only clinical cardiac abnormality found was that of second-degree atrioventricular block. At autopsy, a diffuse carditis, characterized by infiltrates of macrophages, lymphocytes, and eosinophils and primarily in an interstitial, endocardial, and perivascular distribution, was found. Serologic testing from blood drawn on the day before his death demonstrated IgG and IgM antibodies against B. burgdorferi, confirmed by Western blot. Postmortem polymerase chain reaction (PCR) performed in myocardial tissue amplified B. burgdorferi DNA encoding outer-surface protein A. CONCLUSIONS: Lyme carditis should be considered in the differential diagnosis of interstitial myocarditis with mixed inflammatory infiltrates. This diagnosis can be confirmed by PCR testing.
 
PMID: 18329555 [PubMed - in process]

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#3783 De: "juancaqd" <juancaqd@...>
Fecha: Vie, 14 de Mar, 2008 10:24 pm
Asunto: Ticks and mosquitoes as vectors of Borrelia burgdorferi s. l. in the forested areas of Szczecin. 		juancaqd
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1: Folia Biol (Krakow). 2007;55(3-4):143-6.
Links
Ticks and mosquitoes as vectors of Borrelia burgdorferi s. l. in the forested areas of Szczecin.
Kosik-Bogacka DI, Kuźna-Grygiel W, Jaborowska M.
 
Department of Biology and Medical Parasitology, Pomeranian Medical University, Powstancow Wielkopolskich Av. 72, 70-111 Szczecin, Poland. kodan@...
 
The aim of the study was to determine the infection level of adult forms and larvae of ticks and mosquitoes with Borrelia burgdorferi in the forested areas of Szczecin. A total of 1699 ticks Ixodes ricinus, including 1422 nymphs, 277 adult forms and 2862 mosquito females representing the genera Aedes (89.6%) and Culex (10.4%) were collected between the years 2004 and 2005. A further 3746 larvae and 1596 pupae of Culex pipiens pipiens were colleted from water bodies. Borrelia burgdorferi s. l. was detected in the arthropods by the method of indirect immunofluorescence assay (IFA). A positive immunological reaction was detected in 16.6% of the adult forms and in 16.5% of the nymphs of Ixodes ricinus. Spirochetes were also detected in 1.7% of mosquito females, 3.2% of larvae and in 1.6% of pupae of Culex pipiens pipiens. The results of the present study confirm that contact with ticks constitutes the main risk of contracting Lyme disease, although mosquitoes play a role as vectors as well.
 
PMID: 18274258 [PubMed - in process]

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#3782 De: Miguel Ramírez Ortega <ramirezortega@...>
Fecha: Lun, 10 de Mar, 2008 8:49 am
Asunto: Re: [Lyme-E] Persistence of Borrelia burgdorferi Following Antibiotic Treatment in Mice 		miguelramire...
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Aparte de la corta temporada que tomé el régimen de Martin Noble no me he vuelto a arriesgar.
Aquello mejoró mis síntomas, me ayudó a comenzar a recuperar mi forma física, pero también me reagudizó el problema de coagulación que ya había padecido antes,aunque nunca fue tan grave como entonces. Una vez sobrevivido a aquello tengo que reconocer que si no hubiera sido por esos suplementos no me hubieran diagnosticado los embolismos pulmonares porque eran de muy baja intensidad, pero es que un poco más y no lo cuento.
 
Aunque en retrospectiva veo más ventajas que inconvenientes, yo no se lo recomendaría a nadie. Pude no haber tenido tanta suerte...Hay veces que un sólo inconveniente puede anular a mil ventajas.
 
Saludos,
 
Miguel
 
----- Original Message -----
From: juancaqd
Sent: Friday, March 07, 2008 7:10 PM
Subject: Re: [Lyme-E] Persistence of Borrelia burgdorferi Following Antibiotic Treatment in Mice

Miguel, ¿sigues tomando algun suplemento?
saludos,
 
J.C
----- Original Message -----
Sent: Wednesday, March 05, 2008 11:36 AM
Subject: Re: [Lyme-E] Persistence of Borrelia burgdorferi Following Antibiotic Treatment in Mice

Gracias Miguel por esta joya de artículo para enmarcar.
 
Lo del Xenodiagnóstico es una idea macabra que manejo en mi mente desde hace tiempo; cuando intentaba explicar porqué las Borrelias agravaban mis problemas de coagulación cuando viajaba a áreas endémicas de Lyme, y la única explicación que encontraba es que inducían la formación de microtrombos como camuflaje para salir de sus escondites y a través de la sangre ponerse en contacto con nuevas garrapatas que les permitieran completar su ciclo biológico.
 
En la mayoría de estudios en humanos fracasan en encontrar evidencia de la infección, sin embargo en los estudios en animales de experimentación no tienen problema en conseguirlo. Esto es incomprensible pero es un hecho, y la solución sería tan sencilla (como asquerosa) de exponer a los humanos a estudio a unas cuantas garrapatas no infectadas durante unos días y luego analizarlas ¿Fácil no? A ver quien es el guapo que se enrola ahora en un estudio que tenga ese requisito.
Aunque yo antes que volver a sufrir todas las humillaciones por las que me han hecho pasar hubiera preferido llevar unas cuantas garrapatas prendidas, aunque sólo hubiera sido por conseguir un diagnóstico más rápido. Sería un poco como volver a la época de las sanguijuelas en la medicina, pero sin duda mejor que de lo que ahora mismo disponemos.
 
Un saludo,
 
Miguel
 
----- Original Message -----
From: Miguel
Sent: Tuesday, March 04, 2008 9:10 PM
Subject: [Lyme-E] Persistence of Borrelia burgdorferi Following Antibiotic Treatment in Mice

 
AAC Accepts, published online ahead of print on 3 March 2008
Antimicrob. Agents Chemother. doi:10.1128/AAC.01050-07
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Persistence of Borrelia burgdorferi Following Antibiotic Treatment in Mice

Emir Hodzic, Sunlian Feng, Kevin Holden, Kimberly J. Freet, and Stephen W. Barthold*

Center for Comparative Medicine, Schools of Medicine and Veterinary Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616

* To whom correspondence should be addressed. Email: swbarthold@ucdavis.edu .

The effectiveness of antibiotic treatment was examined in a mouse model of Lyme borreliosis. Mice were treated with ceftriaxone or saline for one month, commencing during the early (3 weeks) or chronic (4 months) stages of infection with Borrelia burgdorferi. Tissues from mice were tested for infection by culture, polymerase chain reaction (PCR), xenodiagnosis, and transplantation of allografts at 1 and 3 months after completion of treatment. In addition, tissues were examined for spirochetes by immunohistochemistry. In contrast to saline-treated mice, mice treated with antibiotic were consistently culture-negative, but tissues from some of the mice remained PCR-positive, and spirochetes could be visualized in collagen-rich tissues. Furthermore, when some of the antibiotic treated mice were fed upon by Ixodes scapularis ticks (xenodiagnosis), spirochetes were acquired by the ticks, based upon PCR, and ticks from those cohorts transmitted spirochetes to naïve SCID mice, which became PCR-positive, but culture-negative. Results indicated that following antibiotic treatment, mice remained infected with non-dividing but infectious spirochetes, particularly when antibiotic treatment was commenced during the chronic stage of infection.


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#3781 De: "juancaqd" <juancaqd@...>
Fecha: Do, 9 de Mar, 2008 5:56 pm
Asunto: LINKING HUMAN ANIMAL BIOMEDICAL RESEARCH TO BENEFIT BOTH 		juancaqd
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A profile of Stephen Barthold, author of a recently published study,
"Persistence of Borrelia burgdorferi Following Antibiotic Treatment in
Mice", http://health.groups.yahoo.com/group/LymeInfo/message/4165

- -

LINKING HUMAN ANIMAL BIOMEDICAL RESEARCH TO BENEFIT BOTH
UCDavis Medicine, Spring 2008

A University of California-Davis School of Medicine publication for
alumni, friends and physicians

http://www.ucdmc.ucdavis.edu/ucdavismedicine/issues/Spring2008/features/3.html
or: http://tinyurl.com/yp29jv

No one knew what Lyme disease was when Stephen Barthold's daughter
was diagnosed with it in 1978. At the time, Barthold and his family
were living in Connecticut, the state where the cause of the tickborne
disease would be identified four years later.

While a course of antibiotics for an unrelated infection cured his
daughter, the father remained intrigued. Today, with 30 years of
research and more than 100 papers on Lyme disease under his belt,
Barthold, a veterinary pathologist with a joint appointment in the
schools of Medicine and Veterinary Medicine, is recognized as one of
the leading authorities on how the Lyme bacterium interacts with the
hosts it infects.

...

But, says Barthold, "our work has shown that in the absence of
antibiotic treatment, 100 percent of animals infected with Lyme
bacteria remain infected even though they have a perfectly functional
immune response."

Working with mice, Barthold has found that the bacteria, Borrelia
burgdorferi, "literally integrate themselves into collagen tissue.
They colonize little spots here and there: one joint, but not another;
nervous tissue; the heart. It varies from individual to individual,
which explains the disease's highly variable clinical manifestations."

In a study to be published later this year, Barthold outlines his
discovery that even after long-term antibiotic treatment, bacteria
hidden in collagen tissue are still viable and infectious. "We're
trying to be careful in what we claim," he says, "but these findings
will be controversial."

Full Story:
http://tinyurl.com/yp29jv

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#3780 De: "juancaqd" <juancaqd@...>
Fecha: Vie, 7 de Mar, 2008 6:21 pm
Asunto: Re: [Lyme-E] Analítica del Reumatólogo 		juancaqd
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Es curioso ver como descartan cualquier información
que les lleves o análisis, no se si es porque suponen
a todos sus pacientes mentalmente inferiores o algo
parecido.
Que yo sepa una velocidad alta de sedimentacion
la puede provocar lyme pero no siempre es asi, a
mi aveces me sale alta y a veces normal.
La proteina C reactiva la mayoria de las veces me
ha salido alta, hasta 5 veces el limite superior y
segun he leido las infecciones crónicas bacterianas
pueden elevarla.
 
 
saludos
 
 
----- Original Message -----
From: Luis
Sent: Tuesday, March 04, 2008 8:56 PM
Subject: [Lyme-E] Analítica del Reumatólogo


Hola a tod@s:
Espero y deseo que este silencio que nos embarga en el foro, sea porque
os sintáis al menos relativamente bien. Que no sea porque hemos tirado
la toalla.
Bien, al grano: Tuve una cita con el reumatólogo el día 4 de Febrero y
sobre la marcha me mandó hacer unas radiografías de los codos, porque
últimamente tengo los brazos casi inutilizables por los dolores de los
mismos. Pues bien, aparte de mandarme una analítica (que ya tengo en mi
poder), me dijo que parecía algo del túnel carpiano.
Le enseñé la PCR positiva de Lyme, y como el que vé llover, ni caso.
En la analítica me aparecen elevadas la urea, proteína C reactiva,
plaquetas (VPM) y velocidad de sedimentación. Linfocitos por debajo de
lo normal y Basófilos en 0,0.
Yo, como es normal, pienso y creo que todo esto está alterado por las
dichosas espiroquetas, pero me gustaría que alguno de ustedes me lo
corroborara y os extendiéseis un poco más en el tema, más bien por
vuestras propias experiencias.
Saludos y agradecimientos de Luis.


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#3779 De: "juancaqd" <juancaqd@...>
Fecha: Vie, 7 de Mar, 2008 6:10 pm
Asunto: Re: [Lyme-E] Persistence of Borrelia burgdorferi Following Antibiotic Treatment in Mice 		juancaqd
Sin conexión Sin conexión
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Miguel, ¿sigues tomando algun suplemento?
saludos,
 
J.C
----- Original Message -----
Sent: Wednesday, March 05, 2008 11:36 AM
Subject: Re: [Lyme-E] Persistence of Borrelia burgdorferi Following Antibiotic Treatment in Mice

Gracias Miguel por esta joya de artículo para enmarcar.
 
Lo del Xenodiagnóstico es una idea macabra que manejo en mi mente desde hace tiempo; cuando intentaba explicar porqué las Borrelias agravaban mis problemas de coagulación cuando viajaba a áreas endémicas de Lyme, y la única explicación que encontraba es que inducían la formación de microtrombos como camuflaje para salir de sus escondites y a través de la sangre ponerse en contacto con nuevas garrapatas que les permitieran completar su ciclo biológico.
 
En la mayoría de estudios en humanos fracasan en encontrar evidencia de la infección, sin embargo en los estudios en animales de experimentación no tienen problema en conseguirlo. Esto es incomprensible pero es un hecho, y la solución sería tan sencilla (como asquerosa) de exponer a los humanos a estudio a unas cuantas garrapatas no infectadas durante unos días y luego analizarlas ¿Fácil no? A ver quien es el guapo que se enrola ahora en un estudio que tenga ese requisito.
Aunque yo antes que volver a sufrir todas las humillaciones por las que me han hecho pasar hubiera preferido llevar unas cuantas garrapatas prendidas, aunque sólo hubiera sido por conseguir un diagnóstico más rápido. Sería un poco como volver a la época de las sanguijuelas en la medicina, pero sin duda mejor que de lo que ahora mismo disponemos.
 
Un saludo,
 
Miguel
 
----- Original Message -----
From: Miguel
Sent: Tuesday, March 04, 2008 9:10 PM
Subject: [Lyme-E] Persistence of Borrelia burgdorferi Following Antibiotic Treatment in Mice

 
AAC Accepts, published online ahead of print on 3 March 2008
Antimicrob. Agents Chemother. doi:10.1128/AAC.01050-07
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Persistence of Borrelia burgdorferi Following Antibiotic Treatment in Mice

Emir Hodzic, Sunlian Feng, Kevin Holden, Kimberly J. Freet, and Stephen W. Barthold*

Center for Comparative Medicine, Schools of Medicine and Veterinary Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616

* To whom correspondence should be addressed. Email: swbarthold@ucdavis.edu .

The effectiveness of antibiotic treatment was examined in a mouse model of Lyme borreliosis. Mice were treated with ceftriaxone or saline for one month, commencing during the early (3 weeks) or chronic (4 months) stages of infection with Borrelia burgdorferi. Tissues from mice were tested for infection by culture, polymerase chain reaction (PCR), xenodiagnosis, and transplantation of allografts at 1 and 3 months after completion of treatment. In addition, tissues were examined for spirochetes by immunohistochemistry. In contrast to saline-treated mice, mice treated with antibiotic were consistently culture-negative, but tissues from some of the mice remained PCR-positive, and spirochetes could be visualized in collagen-rich tissues. Furthermore, when some of the antibiotic treated mice were fed upon by Ixodes scapularis ticks (xenodiagnosis), spirochetes were acquired by the ticks, based upon PCR, and ticks from those cohorts transmitted spirochetes to naïve SCID mice, which became PCR-positive, but culture-negative. Results indicated that following antibiotic treatment, mice remained infected with non-dividing but infectious spirochetes, particularly when antibiotic treatment was commenced during the chronic stage of infection.


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#3778 De: "juancaqd" <juancaqd@...>
Fecha: Vie, 7 de Mar, 2008 5:38 pm
Asunto: Majority of ME/CFS patients negatively affected by Cognitive Behaviour Therapy 		juancaqd
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*Majority of ME/CFS patients negatively affected by
Cognitive Behaviour Therapy***

A recent pilot study (Koolhaas, et al., 2008, Netherlands) reports that only
2% of ME/CFS patients are cured by CBT, while the greatest share (38%) are
adversely affected - most reporting substantial deterioration. It is
especially notable that employment and education are negatively affected.
This is in sharp contrast to the claims of psychiatrists and the Dutch
Health Council that 70% of patients improve. Previous studies have also
ignored or denied the negative affects of CBT on ME/CFS patients. The pilot
study, recently published in the Dutch Medical Magazine, Medisch Contact,
concludes that the previously reported claims of 70% improvement in ME/CFS
patients receiving CBT are vastly overstated and misleading.

The following summary is from page 4 of the Dutch-language study.

http://home.planet.nl/~koolh222/cgtbijmecvsvanuitperspectiefpatient2008.pdf

Cognitieve gedragstherapie bij het chronische vermoeidheidssyndroom (ME/CVS)
vanuit het perspectief van de patiënt

Drs. M.P. Koolhaas, H. de Boorder, prof. dr. E. van Hoof
Date: February 2008
ISBN: 978-90-812658-1-2

The Netherlands

*SUMMARY*

*Background
*In recent years, Chronic Fatigue Syndrome, also known as Myalgic
Encephalomyelitis
(ME/CFS), has been getting a lot of attention in scientific literature.
However its aetiology
remains unclear and it has yet to be clarified why some people are more
prone to this
condition than others. Furthermore, there is as yet no consensus about the
treatment of
ME/CFS. The different treatments can be subdivided into two groups, the
pharmacological
and the psychosocial therapies. Most of the scientific articles on treatment
emphasize the
psychosocial approach.

The most intensively studied psychological therapeutic intervention for
ME/CFS is cognitive
behaviour therapy (CBT). In recent years several publications on this
subject have been
published. These studies report that this intervention can lead to
significant improvements in
30% to 70% of patients, though rarely include details of adverse effects.
This pilot study was
undertaken to find out whether patients' experiences with this therapy
confirm the stated
percentages. Furthermore, we examined whether this therapy does influence
the
employment rates, and could possibly increase the number of patients
receiving educational
training, engaged in sports, maintaining social contacts and doing household
tasks.

*Method
*By means of a questionnaire posted at various newsgroups on the internet,
the reported
subjective experiences of 100 respondents who underwent this therapy were
collected.
These experiences were subsequently analysed.

*Results
*Only 2% of respondents reported that they considered themselves to be
completely cured
upon finishing the therapy. Thirty per cent reported 'an improvement' as a
result of the
therapy and the same percentage reported no change. Thirty-eight percent
said the therapy
had affected them adversely, the majority of them even reporting substantial
deterioration.
Participating in CBT proved to have little impact on the number of hours
people were capable
of maintaining social contacts or doing household tasks. A striking outcome
is that the
number of those respondents who were in paid employment or who were studying
while
taking part in CBT was adversely affected. The negative outcome in paid
employment was
statistically significant. CBT did, however, lead to an increase in the
number of patients
taking up sports.

A subgroup analysis showed that those patients who were involved in legal
proceedings in
order to obtain disability benefit while participating in CBT did not score
worse than those
who were not. Cases where a stated objective of the therapy was a complete
cure, did not
have a better outcome. Moreover, the length of the therapy did not affect
the results.

*Conclusions
*This pilot study, based on subjective experiences of ME/CFS sufferers, does
not confirm the
high success rates regularly claimed by research into the effectiveness of
CBT for ME/CFS.
Over all, CBT for ME/CFS does not improve patients' well-being: more
patients report
deterioration of their condition rather than improvement.
Our conclusion is that the claims in scientific publications about the
effectiveness of this
therapy based on trials in strictly controlled settings within universities,
has been overstated
and are therefore misleading. The findings of a subgroup analysis also
contradict reported
findings from research in strictly regulated settings.

For more information, please contact:

Drs. M.P. Koolhaas

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#3777 De: montserrat pérez martínez <mpmcrono@...>
Fecha: Vie, 7 de Mar, 2008 11:57 am
Asunto: RE: [Lyme-E] Analítica del Reumatólogo 		mpmcrono
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  Hola Luis:
 
  Yo no he tirado la toalla, soy muy cabezona, y espero que las fuerzas me acompañen para no tirarla.
 
  Yo tengo diagnosticado sindrome del tunel carpiano, hace muchos años.  Me dijeron que me tenía que operarar (suerte que no lo hice), porque cuando descubrí lo del Lyme, me quedó claro dél porqué de ese problema.
 
  Saludos a todos.
 
  Montse.

Luis Mariano del Toro <nosena77@...> escribió:
Bueno, Miguel:
Agradecido por esta recopilación sobre el túnel carpiano. Otra prueba evidente de que la infección está activa, desgraciadamente sólo para mí.
Y, respecto a la elevación de ciertos parámetros de la analítica, ¿me puedes decir si todo concuerda o puede tener relación con la infección de la borrelia?
Estoy a la espera de una carta del reumatólogo con el diagnóstico, tratamiento (si procede) y derivación al médico de cabecera.
Por otro lado, me alegra que este silencio sea porque nos encontramos mejor, aunque no hay que descuidarse en el tratamiento que mejor nos va.
Te vuelvo a dar las gracias y te mando un abrazo.


To: lyme_y_otras_zoonosis_cronicas_espanol@yahoogroups.com
From: ramirezortega@telefonica.net
Date: Wed, 5 Mar 2008 10:39:13 +0100
Subject: Re: [Lyme-E] Analítica del Reumatólogo

Hola Luis,
 
Te he hecho una recopilación de artículos que relacionan el Lyme como posible causa del Síndrome del Tunel Carpiano (STC), también incluyo un estudio en que no encuentran relación significativa entre STC y presencia de anticuerpos anti-borrelia (seguramente tampoco sería tan significativa como ellos se piensan la relación entre Lyme crónico y presencia de anticuerpos anti-borrelia).
Si te sirve de algo te comento que el STC es una de las quejas más comunes entre los pacientes de foros de Lyme tanto americanos como Europeos que frecuento desde hace 9 años. Y es una de las cosas que puede mejorar, si no resolverse completamente, tratando el Lyme adecuadamente.
 
Pues en mi caso sí, el silencio era poque ya casi me estaba olvidando de lo malito que he estado todos estos años. Hasta que hoy me he levantado con una radiculoneuritis que si no me ayudan no puedo ni levantarme de la cama. Estaba tan bien últimamente que no me cuadraba, así que he revisado mi agenda y resulta que la semana pasada me retrasé un día en mi toma del tinidazol; eso ya lo explica todo: es bueno olvidarse un poco pero no hasta el punto de descuidar tu tratamiento.
 
Saludos,
 
Miguel
 
 
----- Original Message -----
From: Luis
Sent: Tuesday, March 04, 2008 8:56 PM
Subject: [Lyme-E] Analítica del Reumatólogo


Hola a tod@s:
Espero y deseo que este silencio que nos embarga en el foro, sea porque
os sintáis al menos relativamente bien. Que no sea porque hemos tirado
la toalla.
Bien, al grano: Tuve una cita con el reumatólogo el día 4 de Febrero y
sobre la marcha me mandó hacer unas radiografías de los codos, porque
últimamente tengo los brazos casi inutilizables por los dolores de los
mismos. Pues bien, aparte de mandarme una analítica (que ya tengo en mi
poder), me dijo que parecía algo del túnel carpiano.
Le enseñé la PCR positiva de Lyme, y como el que vé llover, ni caso.
En la analítica me aparecen elevadas la urea, proteína C reactiva,
plaquetas (VPM) y velocidad de sedimentación. Linfocitos por debajo de
lo normal y Basófilos en 0,0.
Yo, como es normal, pienso y creo que todo esto está alterado por las
dichosas espiroquetas, pero me gustaría que alguno de ustedes me lo
corroborara y os extendiéseis un poco más en el tema, más bien por
vuestras propias experiencias.
Saludos y agradecimientos de Luis.




Sigue los principales acontecimientos deportivos en directo. MSN Motor


Enviado desde Correo Yahoo!
Disfruta de una bandeja de entrada más inteligente..

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#3776 De: Luis Mariano del Toro <nosena77@...>
Fecha: Mié, 5 de Mar, 2008 7:20 pm
Asunto: RE: [Lyme-E] Analítica del Reumatólogo 		nosena77
Sin conexión Sin conexión
Enviar mensaje Enviar mensaje
 
Bueno, Miguel:
Agradecido por esta recopilación sobre el túnel carpiano. Otra prueba evidente de que la infección está activa, desgraciadamente sólo para mí.
Y, respecto a la elevación de ciertos parámetros de la analítica, ¿me puedes decir si todo concuerda o puede tener relación con la infección de la borrelia?
Estoy a la espera de una carta del reumatólogo con el diagnóstico, tratamiento (si procede) y derivación al médico de cabecera.
Por otro lado, me alegra que este silencio sea porque nos encontramos mejor, aunque no hay que descuidarse en el tratamiento que mejor nos va.
Te vuelvo a dar las gracias y te mando un abrazo.


To: lyme_y_otras_zoonosis_cronicas_espanol@yahoogroups.com
From: ramirezortega@...
Date: Wed, 5 Mar 2008 10:39:13 +0100
Subject: Re: [Lyme-E] Analítica del Reumatólogo

Hola Luis,
 
Te he hecho una recopilación de artículos que relacionan el Lyme como posible causa del Síndrome del Tunel Carpiano (STC), también incluyo un estudio en que no encuentran relación significativa entre STC y presencia de anticuerpos anti-borrelia (seguramente tampoco sería tan significativa como ellos se piensan la relación entre Lyme crónico y presencia de anticuerpos anti-borrelia).
Si te sirve de algo te comento que el STC es una de las quejas más comunes entre los pacientes de foros de Lyme tanto americanos como Europeos que frecuento desde hace 9 años. Y es una de las cosas que puede mejorar, si no resolverse completamente, tratando el Lyme adecuadamente.
 
Pues en mi caso sí, el silencio era poque ya casi me estaba olvidando de lo malito que he estado todos estos años. Hasta que hoy me he levantado con una radiculoneuritis que si no me ayudan no puedo ni levantarme de la cama. Estaba tan bien últimamente que no me cuadraba, así que he revisado mi agenda y resulta que la semana pasada me retrasé un día en mi toma del tinidazol; eso ya lo explica todo: es bueno olvidarse un poco pero no hasta el punto de descuidar tu tratamiento.
 
Saludos,
 
Miguel
 
 
----- Original Message -----
From: Luis
Sent: Tuesday, March 04, 2008 8:56 PM
Subject: [Lyme-E] Analítica del Reumatólogo


Hola a tod@s:
Espero y deseo que este silencio que nos embarga en el foro, sea porque
os sintáis al menos relativamente bien. Que no sea porque hemos tirado
la toalla.
Bien, al grano: Tuve una cita con el reumatólogo el día 4 de Febrero y
sobre la marcha me mandó hacer unas radiografías de los codos, porque
últimamente tengo los brazos casi inutilizables por los dolores de los
mismos. Pues bien, aparte de mandarme una analítica (que ya tengo en mi
poder), me dijo que parecía algo del túnel carpiano.
Le enseñé la PCR positiva de Lyme, y como el que vé llover, ni caso.
En la analítica me aparecen elevadas la urea, proteína C reactiva,
plaquetas (VPM) y velocidad de sedimentación. Linfocitos por debajo de
lo normal y Basófilos en 0,0.
Yo, como es normal, pienso y creo que todo esto está alterado por las
dichosas espiroquetas, pero me gustaría que alguno de ustedes me lo
corroborara y os extendiéseis un poco más en el tema, más bien por
vuestras propias experiencias.
Saludos y agradecimientos de Luis.




Sigue los principales acontecimientos deportivos en directo. MSN Motor

Responder | Reenviar | Mensajes en este tema (4)
#3775 De: Luis Mariano del Toro <nosena77@...>
Fecha: Mié, 5 de Mar, 2008 6:15 pm
Asunto: RE: [Lyme-E] Persistence of Borrelia burgdorferi Following Antibiotic Treatment in Mice 		nosena77
Sin conexión Sin conexión
Enviar mensaje Enviar mensaje
 
A mí, particularmente, no me importaría someterme durante 48 horas a unas cuantas garrapatas si con esto se demostrase su positividad. Pero, después de lo visto (me refiero a tantos especialistas) y de lo que comentas que es incomprensible, no me presto a nada, porque sigo pensando en digámosle, cierta conspiración. No tengo más remedio que pensar así, puesto que se les pone por delante lo que es evidente, además de la anamnesis de tantos años, el eritema migratorio (que ya lo dice casi todo), y siguen haciendo caso omiso u oído sordo a una enfermedad que está reconocida por la Medicina como tal. ¿Es para pensar que algo raro ocurre?, ¿sí o no?

To: lyme_y_otras_zoonosis_cronicas_espanol@yahoogroups.com
From: ramirezortega@...
Date: Wed, 5 Mar 2008 11:36:52 +0100
Subject: Re: [Lyme-E] Persistence of Borrelia burgdorferi Following Antibiotic Treatment in Mice

Gracias Miguel por esta joya de artículo para enmarcar.
 
Lo del Xenodiagnóstico es una idea macabra que manejo en mi mente desde hace tiempo; cuando intentaba explicar porqué las Borrelias agravaban mis problemas de coagulación cuando viajaba a áreas endémicas de Lyme, y la única explicación que encontraba es que inducían la formación de microtrombos como camuflaje para salir de sus escondites y a través de la sangre ponerse en contacto con nuevas garrapatas que les permitieran completar su ciclo biológico.
 
En la mayoría de estudios en humanos fracasan en encontrar evidencia de la infección, sin embargo en los estudios en animales de experimentación no tienen problema en conseguirlo. Esto es incomprensible pero es un hecho, y la solución sería tan sencilla (como asquerosa) de exponer a los humanos a estudio a unas cuantas garrapatas no infectadas durante unos días y luego analizarlas ¿Fácil no? A ver quien es el guapo que se enrola ahora en un estudio que tenga ese requisito.
Aunque yo antes que volver a sufrir todas las humillaciones por las que me han hecho pasar hubiera preferido llevar unas cuantas garrapatas prendidas, aunque sólo hubiera sido por conseguir un diagnóstico más rápido. Sería un poco como volver a la época de las sanguijuelas en la medicina, pero sin duda mejor que de lo que ahora mismo disponemos.
 
Un saludo,
 
Miguel
 
----- Original Message -----
From: Miguel
Sent: Tuesday, March 04, 2008 9:10 PM
Subject: [Lyme-E] Persistence of Borrelia burgdorferi Following Antibiotic Treatment in Mice

 
AAC Accepts, published online ahead of print on 3 March 2008
Antimicrob. Agents Chemother. doi:10.1128/AAC.01050-07
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Persistence of Borrelia burgdorferi Following Antibiotic Treatment in Mice

Emir Hodzic, Sunlian Feng, Kevin Holden, Kimberly J. Freet, and Stephen W. Barthold*

Center for Comparative Medicine, Schools of Medicine and Veterinary Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616

* To whom correspondence should be addressed. Email: swbarthold@ucdavis.edu .

The effectiveness of antibiotic treatment was examined in a mouse model of Lyme borreliosis. Mice were treated with ceftriaxone or saline for one month, commencing during the early (3 weeks) or chronic (4 months) stages of infection with Borrelia burgdorferi. Tissues from mice were tested for infection by culture, polymerase chain reaction (PCR), xenodiagnosis, and transplantation of allografts at 1 and 3 months after completion of treatment. In addition, tissues were examined for spirochetes by immunohistochemistry. In contrast to saline-treated mice, mice treated with antibiotic were consistently culture-negative, but tissues from some of the mice remained PCR-positive, and spirochetes could be visualized in collagen-rich tissues. Furthermore, when some of the antibiotic treated mice were fed upon by Ixodes scapularis ticks (xenodiagnosis), spirochetes were acquired by the ticks, based upon PCR, and ticks from those cohorts transmitted spirochetes to naïve SCID mice, which became PCR-positive, but culture-negative. Results indicated that following antibiotic treatment, mice remained infected with non-dividing but infectious spirochetes, particularly when antibiotic treatment was commenced during the chronic stage of infection.




Sigue al minuto las principales noticias de tu ciudad MSN Deportes

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#3774 De: Miguel Ramírez Ortega <ramirezortega@...>
Fecha: Mié, 5 de Mar, 2008 10:36 am
Asunto: Re: [Lyme-E] Persistence of Borrelia burgdorferi Following Antibiotic Treatment in Mice 		miguelramire...
Sin conexión Sin conexión
Enviar mensaje Enviar mensaje
 
Gracias Miguel por esta joya de artículo para enmarcar.
 
Lo del Xenodiagnóstico es una idea macabra que manejo en mi mente desde hace tiempo; cuando intentaba explicar porqué las Borrelias agravaban mis problemas de coagulación cuando viajaba a áreas endémicas de Lyme, y la única explicación que encontraba es que inducían la formación de microtrombos como camuflaje para salir de sus escondites y a través de la sangre ponerse en contacto con nuevas garrapatas que les permitieran completar su ciclo biológico.
 
En la mayoría de estudios en humanos fracasan en encontrar evidencia de la infección, sin embargo en los estudios en animales de experimentación no tienen problema en conseguirlo. Esto es incomprensible pero es un hecho, y la solución sería tan sencilla (como asquerosa) de exponer a los humanos a estudio a unas cuantas garrapatas no infectadas durante unos días y luego analizarlas ¿Fácil no? A ver quien es el guapo que se enrola ahora en un estudio que tenga ese requisito.
Aunque yo antes que volver a sufrir todas las humillaciones por las que me han hecho pasar hubiera preferido llevar unas cuantas garrapatas prendidas, aunque sólo hubiera sido por conseguir un diagnóstico más rápido. Sería un poco como volver a la época de las sanguijuelas en la medicina, pero sin duda mejor que de lo que ahora mismo disponemos.
 
Un saludo,
 
Miguel
 
----- Original Message -----
From: Miguel
Sent: Tuesday, March 04, 2008 9:10 PM
Subject: [Lyme-E] Persistence of Borrelia burgdorferi Following Antibiotic Treatment in Mice

 
AAC Accepts, published online ahead of print on 3 March 2008
Antimicrob. Agents Chemother. doi:10.1128/AAC.01050-07
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Persistence of Borrelia burgdorferi Following Antibiotic Treatment in Mice

Emir Hodzic, Sunlian Feng, Kevin Holden, Kimberly J. Freet, and Stephen W. Barthold*

Center for Comparative Medicine, Schools of Medicine and Veterinary Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616

* To whom correspondence should be addressed. Email: swbarthold@ucdavis.edu .

The effectiveness of antibiotic treatment was examined in a mouse model of Lyme borreliosis. Mice were treated with ceftriaxone or saline for one month, commencing during the early (3 weeks) or chronic (4 months) stages of infection with Borrelia burgdorferi. Tissues from mice were tested for infection by culture, polymerase chain reaction (PCR), xenodiagnosis, and transplantation of allografts at 1 and 3 months after completion of treatment. In addition, tissues were examined for spirochetes by immunohistochemistry. In contrast to saline-treated mice, mice treated with antibiotic were consistently culture-negative, but tissues from some of the mice remained PCR-positive, and spirochetes could be visualized in collagen-rich tissues. Furthermore, when some of the antibiotic treated mice were fed upon by Ixodes scapularis ticks (xenodiagnosis), spirochetes were acquired by the ticks, based upon PCR, and ticks from those cohorts transmitted spirochetes to naïve SCID mice, which became PCR-positive, but culture-negative. Results indicated that following antibiotic treatment, mice remained infected with non-dividing but infectious spirochetes, particularly when antibiotic treatment was commenced during the chronic stage of infection.


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#3773 De: Miguel Ramírez Ortega <ramirezortega@...>
Fecha: Mié, 5 de Mar, 2008 9:39 am
Asunto: Re: [Lyme-E] Analítica del Reumatólogo 		miguelramire...
Sin conexión Sin conexión
Enviar mensaje Enviar mensaje
 
Hola Luis,
 
Te he hecho una recopilación de artículos que relacionan el Lyme como posible causa del Síndrome del Tunel Carpiano (STC), también incluyo un estudio en que no encuentran relación significativa entre STC y presencia de anticuerpos anti-borrelia (seguramente tampoco sería tan significativa como ellos se piensan la relación entre Lyme crónico y presencia de anticuerpos anti-borrelia).
Si te sirve de algo te comento que el STC es una de las quejas más comunes entre los pacientes de foros de Lyme tanto americanos como Europeos que frecuento desde hace 9 años. Y es una de las cosas que puede mejorar, si no resolverse completamente, tratando el Lyme adecuadamente.
 
Pues en mi caso sí, el silencio era poque ya casi me estaba olvidando de lo malito que he estado todos estos años. Hasta que hoy me he levantado con una radiculoneuritis que si no me ayudan no puedo ni levantarme de la cama. Estaba tan bien últimamente que no me cuadraba, así que he revisado mi agenda y resulta que la semana pasada me retrasé un día en mi toma del tinidazol; eso ya lo explica todo: es bueno olvidarse un poco pero no hasta el punto de descuidar tu tratamiento.
 
Saludos,
 
Miguel
 
 
----- Original Message -----
From: Luis
Sent: Tuesday, March 04, 2008 8:56 PM
Subject: [Lyme-E] Analítica del Reumatólogo


Hola a tod@s:
Espero y deseo que este silencio que nos embarga en el foro, sea porque
os sintáis al menos relativamente bien. Que no sea porque hemos tirado
la toalla.
Bien, al grano: Tuve una cita con el reumatólogo el día 4 de Febrero y
sobre la marcha me mandó hacer unas radiografías de los codos, porque
últimamente tengo los brazos casi inutilizables por los dolores de los
mismos. Pues bien, aparte de mandarme una analítica (que ya tengo en mi
poder), me dijo que parecía algo del túnel carpiano.
Le enseñé la PCR positiva de Lyme, y como el que vé llover, ni caso.
En la analítica me aparecen elevadas la urea, proteína C reactiva,
plaquetas (VPM) y velocidad de sedimentación. Linfocitos por debajo de
lo normal y Basófilos en 0,0.
Yo, como es normal, pienso y creo que todo esto está alterado por las
dichosas espiroquetas, pero me gustaría que alguno de ustedes me lo
corroborara y os extendiéseis un poco más en el tema, más bien por
vuestras propias experiencias.
Saludos y agradecimientos de Luis.


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#3772 De: Miguel Ramírez Ortega <ramirezortega@...>
Fecha: Mié, 5 de Mar, 2008 9:06 am
Asunto: A bilateral carpal tunnel syndrome and local synovitis was diagnosed...The patient improved after a 2-week course of intravenous ceftriaxone 		miguelramire...
Sin conexión Sin conexión
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Wien Klin Wochenschr. 2005 Jun;117(11-12):429-32. Links

Lyme borreliosis in Portugal caused by Borrelia lusitaniae? Clinical report on the first patient with a positive skin isolate.

da Franca I, Santos L, Mesquita T, Collares-Pereira M, Baptista S, Vieira L, Viana I, Vale E, Prates C.

Outpatients Clinic of Dermatology at the Tropical Diseases Unity of the Institute of Hygiene and Tropical Medicine, University Nova de Lisboa, Lisboa, Portugal. ifranca@...

BACKGROUND: Borrelia lusitaniae was isolated from an Ixodes ricinus tick in Portugal in 1993 for the first time. Further, this borrelia genospecies has been found in ixodid ticks collected around the coasts of southern Portugal and North Africa. Its reservoir has not been defined yet. B. lusitaniae was isolated once until now from a patient with a long standing and expanding skin disorder. PATIENT AND METHODS: A 46-year-old Portuguese woman presented with a skin lesion on the left thigh which had evolved slowly over ten years. The patient reported limb paraesthesias, cramps, chronic headaches, and cardiac rhythm disturbances. History of tick bites was negative nor had the patient ever noticed a skin lesion comparable with erythema chronicum migrans. Skin biopsies were taken for histological evaluation, culture and DNA detection. Antibodies to borrelia were searched by indirect immunofluorescence assay and Western-blot. RESULTS: A bilateral carpal tunnel syndrome and local synovitis was diagnosed. Dermato-histology was normal, serology was negative. Spirochaetal organisms were cultured from a skin biopsy and identified as B. lusitaniae. The patient improved after a 2-week course of intravenous ceftriaxone; the skin lesions did not expand further. CONCLUSIONS: This culture confirmed skin infection by B. lusitaniae in a patient from Portugal suggests an additional human pathogen out of the B. burgdorferi sensu lato complex in Europe, particularly in Portugal.

PMID: 16053200 [PubMed - indexed for MEDLINE]


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#3771 De: Miguel Ramírez Ortega <ramirezortega@...>
Fecha: Mié, 5 de Mar, 2008 8:56 am
Asunto: Lyme arthritis was diagnosed in five cases. Carpal tunnel syndrome was the presenting clinical feature in two of them 		miguelramire...
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Br J Rheumatol. 1996 Sep;35(9):853-60.Click here to read Links

Lyme borreliosis in rheumatological practice: identification of Lyme arthritis and diagnostic aspects in a Swedish county with high endemicity.

Berglund J, Blomberg I, Hansen BU.

Ronneby Health Centre, Sweden.

To prospectively study the prevalence of Lyme arthritis, 100 consecutive patients referred to a rheumatology out-patient clinic and 115 patients with a classified rheumatological disease were included. Individuals seropositive for antibody against the Borrelia burgdorferi sensu lato complex were examined for clinical signs or a history of Lyme borreliosis. Positive titres against B. burgdorferi s.l. were found in 7/100 and 15/115, respectively. Among the 100 referred patients. Lyme arthritis was diagnosed in five cases. Carpal tunnel syndrome was the presenting clinical feature in two of them. One of the 115 individuals with a previously classified rheumatological disease was re-classified as Lyme arthritis. All cases of Lyme arthritis improved after oral antibiotic treatment. This study revealed Lyme arthritis to be a common disorder in this part of Sweden and the diagnosis should be considered in patients with acute or recurrent episodes of mono- or oligoarthritis.

PMID: 8810668 [PubMed - indexed for MEDLINE]


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#3770 De: Miguel Ramírez Ortega <ramirezortega@...>
Fecha: Mié, 5 de Mar, 2008 8:49 am
Asunto: Whether the manifestation of bilateral carpal tunnel syndrome is connected with Lyme borreliosis is yet to be clarified 		miguelramire...
Sin conexión Sin conexión
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Handchir Mikrochir Plast Chir. 1995 Sep;27(5):242-6. Links

[Lyme borreliosis in hand surgery. A case report]

[Article in German]

Ebert B, Ganser J.

Berufsgenossenschaftlichen Unfalklinik Tübingen, Abteilung für Anaesthesie und Intensivmedizin.

The clinical courses of Borrelia burgdorferi infections may show such variety, that diagnostic problems arise. On the other hand, early antibiotic therapy is necessary in order to prevent late-term complications. In this article, we present an exceptional case of a long-term documentation of Lyme-disease which was not diagnosed until an acrodermatitis chronica atrophicans had developed. Whether the manifestation of bilateral carpal tunnel syndrome is connected with Lyme borreliosis is yet to be clarified.

PMID: 7498838 [PubMed - indexed for MEDLINE]


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#3769 De: Miguel Ramírez Ortega <ramirezortega@...>
Fecha: Mié, 5 de Mar, 2008 8:47 am
Asunto: neurologic problems following infection by Borrelia burgdorferi,: ...carpal tunnel syndrome 		miguelramire...
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Pediatr Neurol. 1992 Nov-Dec;8(6):428-31. Links

MRI findings in children infected by Borrelia burgdorferi.

Belman AL, Coyle PK, Roque C, Cantos E.

Department of Neurology, School of Medicine, State University of New York, Stony Brook 11794.

Cranial magnetic resonance imaging abnormalities were observed in 8 children (5 boys, 3 girls; ages 4-14 years) with neurologic problems following infection by Borrelia burgdorferi, the etiologic agent of Lyme disease. Neurologic features included headache (6), behavioral changes (5), facial palsy (2), papilledema (2), papilledema with diplopia (1), disturbance of sleep pattern (2), and carpal tunnel syndrome (1). Two MRI studies demonstrated multiple focal areas of increased signal intensity in white matter on long TR (both proton-density and T2-weighted) images.

PMID: 1476570 [PubMed - indexed for MEDLINE]


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#3768 De: Miguel Ramírez Ortega <ramirezortega@...>
Fecha: Mié, 5 de Mar, 2008 8:41 am
Asunto: patients with late Lyme disease 25% had the carpal tunnel syndrome 		miguelramire...
Sin conexión Sin conexión
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Brain. 1990 Aug;113 ( Pt 4):1207-21.Click here to read Links

Lyme neuroborreliosis. Peripheral nervous system manifestations.

Halperin J, Luft BJ, Volkman DJ, Dattwyler RJ.

Department of Neurology, State University of New York, Stony Brook 11794.

An ever increasing number of apparently unrelated peripheral nervous system (PNS) disorders has been associated with Lyme borreliosis. To ascertain their relative frequency and significance, we studied prospectively 74 consecutive patients with late Lyme disease, with and without PNS symptoms: 53% had intermittent limb paraesthesiae, 25% the carpal tunnel syndrome, 8% painful radiculopathy, and 3% Bell's palsy; 39% had disseminated neurophysiological abnormalities. To assess the interrelationships among these syndromes, we reviewed the neurophysiological findings in all 163 such patients that we have studied to date. Reversible abnormalities of distal conduction were the most common finding. Demyelinating neuropathy was extremely rare. The pattern of abnormality was similar in all patient groups, regardless of whether the symptoms suggested radiculopathy, Bell's palsy, or neuropathy. We conclude that (1) reversible PNS abnormalities occur in one-third of our patients with late Lyme borreliosis, and (2) the pattern of electrophysiological abnormalities is the same in all and is indicative of widespread axonal damage, suggesting that these different presentations reflect varying manifestations of the same pathological process.

PMID: 2168778 [PubMed - indexed for MEDLINE]


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#3767 De: Miguel Ramírez Ortega <ramirezortega@...>
Fecha: Mié, 5 de Mar, 2008 8:32 am
Asunto: Antibodies to Borrelia burgdorferi in patients with carpal tunnel syndrome. 		miguelramire...
Sin conexión Sin conexión
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Acta Neurol Scand. 1992 Jul;86(1):73-5. Links

Antibodies to Borrelia burgdorferi in patients with carpal tunnel syndrome.

Kindstrand E.

Department of Neurology, Karolinska Institute Söder Hospital, Stockholm, Sweden.

In a study of 94 consecutive patients with neurophysiologically verified carpal tunnel syndrome (CTS) 7/94 had IgG and 0/94 IgM serum titers to Borrelia burgdorferi above the 98th percentile value of age and sex matched controls (n = 127). The difference in prevalence of positive IgG serum titers in patients, compared to controls, was not statistically significant. Even in patients, living in an area, highly endemic for Lyme borreliosis, routine serological screening for borrelia infection does not seem indicated in the investigation of CTS.

PMID: 1519478 [PubMed - indexed for MEDLINE]


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#3766 De: Miguel Ramírez Ortega <ramirezortega@...>
Fecha: Mié, 5 de Mar, 2008 8:29 am
Asunto: Carpal tunnel syndrome in Lyme borreliosis. 		miguelramire...
Sin conexión Sin conexión
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Muscle Nerve. 1989 May;12(5):397-400. Links

Carpal tunnel syndrome in Lyme borreliosis.

Halperin JJ, Volkman DJ, Luft BJ, Dattwyler RJ.

Department of Neurology, State University of New York, Stony Brook 11794.

Neurophysiologic evidence of median nerve entrapment in the carpal tunnel was present in 25% of patients with late Lyme borreliosis. Sixty-eight of 76 consecutive, prospectively studied patients with late Lyme underwent neurophysiologic testing. Nineteen reported intermittent hand paresthesias; 17 had neurophysiologically confirmed carpal tunnel syndrome. This was not consistently associated with clinically apparent wrist arthritis or with neurophysiologically evident peripheral neuropathy. We conclude that a significant proportion of patients with late Lyme borreliosis develop carpal tunnel syndrome.

PMID: 2725567 [PubMed - indexed for MEDLINE]


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#3765 De: "Miguel" <mikijean@...>
Fecha: Mar, 4 de Mar, 2008 8:10 pm
Asunto: Persistence of Borrelia burgdorferi Following Antibiotic Treatment in Mice 		mikijean@...
Enviar mensaje Enviar mensaje
 
 
AAC Accepts, published online ahead of print on 3 March 2008
Antimicrob. Agents Chemother. doi:10.1128/AAC.01050-07
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Persistence of Borrelia burgdorferi Following Antibiotic Treatment in Mice

Emir Hodzic, Sunlian Feng, Kevin Holden, Kimberly J. Freet, and Stephen W. Barthold*

Center for Comparative Medicine, Schools of Medicine and Veterinary Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616

* To whom correspondence should be addressed. Email: swbarthold@... .

The effectiveness of antibiotic treatment was examined in a mouse model of Lyme borreliosis. Mice were treated with ceftriaxone or saline for one month, commencing during the early (3 weeks) or chronic (4 months) stages of infection with Borrelia burgdorferi. Tissues from mice were tested for infection by culture, polymerase chain reaction (PCR), xenodiagnosis, and transplantation of allografts at 1 and 3 months after completion of treatment. In addition, tissues were examined for spirochetes by immunohistochemistry. In contrast to saline-treated mice, mice treated with antibiotic were consistently culture-negative, but tissues from some of the mice remained PCR-positive, and spirochetes could be visualized in collagen-rich tissues. Furthermore, when some of the antibiotic treated mice were fed upon by Ixodes scapularis ticks (xenodiagnosis), spirochetes were acquired by the ticks, based upon PCR, and ticks from those cohorts transmitted spirochetes to naïve SCID mice, which became PCR-positive, but culture-negative. Results indicated that following antibiotic treatment, mice remained infected with non-dividing but infectious spirochetes, particularly when antibiotic treatment was commenced during the chronic stage of infection.


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